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Resistin Concentration in Early Sepsis and All-Cause Mortality at a Safety-Net Hospital in Riverside County
Jeffrey Bonenfant1,2, Jiang Li3, Luqman Nasouf1
1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Riverside University Health System Medical Center, Moreno Valley, CA, USA.
Journal of Inflammation Research
|July 21, 2022
Summary
Early plasma resistin levels can predict sepsis mortality. Elevated resistin concentrations correlate with disease severity scores and are associated with increased mortality risk in sepsis patients.
Area of Science:
- Biochemistry
- Immunology
- Critical Care Medicine
Background:
- Sepsis mortality rates remain high, underscoring the need for early recognition and improved prognostic markers.
- Plasma resistin levels are elevated in sepsis, but its precise role and clinical significance are not fully understood.
- Resistin's interaction with toll-like receptor 4 suggests a potential link to bacterial infections, but its influence based on infection type is unknown.
Purpose of the Study:
- To determine if early plasma resistin concentration can predict sepsis-related mortality.
- To investigate the association between elevated plasma resistin levels and clinical disease severity scores (SOFA, mSOFA, APACHE II).
- To compare plasma resistin concentrations between gram-negative sepsis and other etiologies.
Main Methods:
- Prospective observational study involving intensive care unit patients with sepsis.
- Collection of peripheral venous blood samples at 0, 6, and 24 hours post-sepsis recognition for resistin and cytokine analysis (IL-6, IL-8, IL-10).
- Correlation of resistin and cytokine levels with clinical severity scores and RNA expression datasets; 60-day mortality follow-up.
Main Results:
- Elevated resistin levels were observed in sepsis patients, with higher concentrations in non-survivors.
- Resistin concentrations >126 ng/mL at sepsis recognition and >197 ng/mL within 24 hours were associated with 60-day mortality (AUC 0.82 and 0.88, respectively).
- Resistin levels correlated significantly with SOFA, mSOFA, and APACHE II scores, as well as inflammatory biomarkers.
Conclusions:
- Plasma resistin concentrations above specific thresholds at early stages of sepsis are significant predictors of all-cause mortality.
- Resistin's predictive value for mortality is comparable to established clinical severity indices.
- These findings highlight resistin as a potential early biomarker for sepsis prognosis.
