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Pharmacological Approaches to Decelerate Aging: A Promising Path
Bahareh Hassani1,2, Ghazal Goshtasbi1,2, Shirin Nooraddini1,2
1Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Oxidative Medicine and Cellular Longevity
|July 21, 2022
Summary
Biological aging, marked by declining cellular function, is a key risk factor for chronic diseases. Targeting aging mechanisms offers a promising therapeutic strategy for numerous age-related conditions.
Area of Science:
- Gerontology and cellular biology
- Molecular mechanisms of aging
Background:
- Biological aging involves decreased cellular function due to altered signaling in stressed cells.
- Aging is a primary risk factor for major chronic illnesses, including cancer, cardiovascular, and neurodegenerative diseases.
- Therapeutic targeting of fundamental aging processes could impact multiple chronic conditions.
Purpose of the Study:
- To explore the mechanisms underlying biological aging.
- To review key cellular and signaling pathways involved in aging, including mTOR, SIRT1, and AMPK.
- To discuss the roles of inflammation and autophagy in the aging process.
Main Methods:
- Review of scientific literature on aging mechanisms.
- Focus on cellular signaling pathways such as mTOR, SIRT1, and AMPK.
- Analysis of the involvement of inflammation and autophagy in aging.
Main Results:
- Aging is characterized by declining cellular function and is linked to specific signaling pathway alterations.
- Key pathways implicated in aging include mTOR, SIRT1, and AMPK.
- Inflammation and autophagy play significant roles in the aging process.
Conclusions:
- Understanding aging mechanisms, particularly key pathways, is crucial for developing interventions.
- Therapeutic strategies targeting aging may offer a unified approach to managing multiple chronic diseases.
- Lifestyle modifications and pharmacological agents, including natural products, show potential in modulating aging.
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