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Updated: Sep 4, 2025

Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Pharmacological Approaches to Decelerate Aging: A Promising Path

Bahareh Hassani1,2, Ghazal Goshtasbi1,2, Shirin Nooraddini1,2

  • 1Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Oxidative Medicine and Cellular Longevity
|July 21, 2022
PubMed

Insights

Biological aging, marked by declining cellular function, is a key risk factor for chronic diseases. Targeting aging mechanisms offers a promising therapeutic strategy for numerous age-related conditions.

Area of Science:

  • Gerontology and cellular biology
  • Molecular mechanisms of aging

Background:

  • Biological aging involves decreased cellular function due to altered signaling in stressed cells.
  • Aging is a primary risk factor for major chronic illnesses, including cancer, cardiovascular, and neurodegenerative diseases.
  • Therapeutic targeting of fundamental aging processes could impact multiple chronic conditions.

Purpose of the Study:

  • To explore the mechanisms underlying biological aging.
  • To review key cellular and signaling pathways involved in aging, including mTOR, SIRT1, and AMPK.
  • To discuss the roles of inflammation and autophagy in the aging process.

Main Methods:

  • Review of scientific literature on aging mechanisms.
  • Focus on cellular signaling pathways such as mTOR, SIRT1, and AMPK.
  • Analysis of the involvement of inflammation and autophagy in aging.

Main Results:

  • Aging is characterized by declining cellular function and is linked to specific signaling pathway alterations.
  • Key pathways implicated in aging include mTOR, SIRT1, and AMPK.
  • Inflammation and autophagy play significant roles in the aging process.

Conclusions:

  • Understanding aging mechanisms, particularly key pathways, is crucial for developing interventions.
  • Therapeutic strategies targeting aging may offer a unified approach to managing multiple chronic diseases.
  • Lifestyle modifications and pharmacological agents, including natural products, show potential in modulating aging.

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