Related Experiment Video
Updated: Sep 4, 2025
09:01
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.2K
Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy.
Shuntao Wang1,2, Ning Zeng3, Qi Zhang3
1Department of Molecular Pathology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in Oncology
|July 21, 2022
Summary
This study introduces a novel hydrogel for cancer therapy, combining photothermal therapy and sonodynamic therapy. The hydrogel releases oxygen to enhance treatment, effectively inhibiting tumor growth.
Area of Science:
- Biomedical Engineering
- Oncology
- Materials Science
Background:
- Sonodynamic therapy (SDT) is a promising cancer treatment, but tumor hypoxia limits its effectiveness.
- Continuous oxygen consumption during SDT exacerbates the hypoxic tumor microenvironment, reducing therapeutic outcomes.
Purpose of the Study:
- To design a multifunctional hydrogel for enhanced photothermal therapy (PTT) and SDT.
- To overcome tumor hypoxia by co-delivering a nanozyme and a sonosensitizer.
Main Methods:
- A novel hydrogel (PB+Ce6@Hy) was developed to co-deliver Prussian blue (PB) nanozyme and chlorin e6 (Ce6) sonosensitizer.
- Local injection followed by 808 nm laser irradiation triggered hydrogel softening and controlled release of PB and Ce6.
- PB generated oxygen from endogenous H2O2 to enhance Ce6-mediated SDT.
Main Results:
- The PB+Ce6@Hy system effectively generated reactive oxygen species (ROS) and exhibited a photothermal effect.
- Combined PTT and enhanced SDT significantly inhibited tumor cell proliferation.
- Controlled release of nanomaterials was achieved by adjusting laser parameters.
Conclusions:
- The developed hydrogel system offers a synergistic PTT/SDT approach for cancer therapy.
- This strategy effectively addresses tumor hypoxia and enhances anti-tumor efficacy.
- The multifunctional hydrogel shows significant potential for clinical translation in cancer treatment.
