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Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Wangmeng Zhang1, Qishan Wu2, Juan Su3

  • 1Department of Obstetrics, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000 Shandong Province, China.

Disease Markers
|July 21, 2022
PubMed
Abstract

Insights

This study identified nine shared circulating microRNAs (miRNAs) linking maternal periodontal disease and preeclampsia. These miRNAs may epigenetically mediate the biological association between these conditions.

Area of Science:

  • Bioinformatics
  • Genomics
  • Reproductive Health

Background:

  • Periodontal disease is linked to pregnancy complications like preeclampsia.
  • Circulating microRNAs (miRNAs) are investigated as potential mediators.

Purpose of the Study:

  • To identify shared circulating miRNAs between maternal periodontal disease and preeclampsia.
  • To explore the biological mechanisms underlying this association.

Main Methods:

  • Bioinformatic analysis of peripheral blood miRNA profiles from public databases (GEO, HMDD v3.0).
  • Differential expression analysis and Venn diagrams to identify shared miRNAs.
  • Enrichment analysis of target genes, KEGG pathways, GO terms, WikiPathways, and BioCarta pathways.

Main Results:

  • Nine shared differentially expressed miRNAs (DEmiRNAs) were identified between periodontitis and preeclampsia.
  • Enrichment analysis revealed key target genes (e.g., MAFB, PSAP), pathways (e.g., renin-angiotensin system), and GO terms (e.g., "positive regulation of epidermal growth factor-activated receptor activity").
  • Specific WikiPathways (e.g., "NAD metabolism") and BioCarta pathways (e.g., PPAR-related mechanisms) were also identified.

Conclusions:

  • A set of nine circulating miRNAs significantly links periodontitis and preeclampsia.
  • These miRNAs and associated pathways may represent epigenetic mediators of the periodontitis-preeclampsia association.

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