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Association Between Thyroid Dysfunction and Incidence of Atrial Fibrillation in Patients With Hypertrophic

Xiangbin Meng1, Xu-Liang Wang2,1, Zhi-Yuan Zhang3

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

Frontiers in Endocrinology
|July 21, 2022
PubMed

Insights

Thyroid dysfunction increases atrial fibrillation risk in hypertrophic obstructive cardiomyopathy (HOCM) patients. Both high and low thyroid-stimulating hormone (TSH) levels are linked to higher AF incidence.

Area of Science:

  • Cardiology
  • Endocrinology

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is a significant cardiovascular condition.
  • Atrial fibrillation (AF) is a common complication in HOCM patients.
  • The role of thyroid dysfunction in AF development within HOCM is not fully understood.

Purpose of the Study:

  • To investigate the association between thyroid dysfunction and the incidence of atrial fibrillation (AF) in patients diagnosed with hypertrophic obstructive cardiomyopathy (HOCM).

Main Methods:

  • Thyroid function tests were performed on 755 HOCM patients.
  • Patients were stratified into four groups based on thyroid-stimulating hormone (TSH) levels.
  • Statistical analysis, including logistic regression, was used to determine correlations.

Main Results:

  • The overall incidence of AF in the HOCM cohort was 14%.
  • Patients with AF exhibited older age, higher NT-proBNP, elevated creatinine, larger left atrial diameter, lower FT3, and higher FT4 levels.
  • Both subnormal (<0.55 mIU/L) and elevated (≥2.50 mIU/L) TSH levels were associated with a significantly increased incidence of AF compared to euthyroid levels (0.55-2.49 mIU/L).

Conclusions:

  • Thyroid dysfunction, characterized by abnormal TSH levels, is significantly associated with an increased risk of developing atrial fibrillation in patients with HOCM.
  • These findings highlight the importance of monitoring thyroid function in HOCM patients to potentially mitigate AF risk.
Abstract

Keywords:
TSHatrial fibrillationhypertrophic obstructive cardiomyopathyrisk factorsthyroid dysfunction

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