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Advances and Trends in Omics Technology Development.

Xiaofeng Dai1, Li Shen1

  • 1Wuxi School of Medicine, Jiangnan University, Wuxi, China.

Frontiers in Medicine
|July 21, 2022
PubMed
Summary
This summary is machine-generated.

Advancements in omics technologies like genomics and proteomics offer insights into cellular systems. This review explores omics hierarchies and future directions for disease control with minimal cell perturbation.

Keywords:
mass spectrometrynext generation sequencingomicsredoxomicsthird generation sequencing

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Area of Science:

  • Biotechnology
  • Systems Biology
  • Genomics

Background:

  • High-throughput sequencing and mass spectrometry have driven the
  • omics
  • revolution, enabling systematic cellular interrogation.
  • The discovery of new molecules and regulatory mechanisms continually refines our understanding of cellular machinery.
  • The expanding scope of omics presents challenges in fully harnessing cellular system knowledge.

Purpose of the Study:

  • To review existing and emerging omics technologies and their applications.
  • To delineate the hierarchies of major omics layers, including genomics, transcriptomics, proteomics, and metabolomics.
  • To predict future directions for translating omics data into disease control strategies with minimal cellular disruption.

Main Methods:

  • Focus on the "four big omics": genomics, transcriptomics, proteomics, and metabolomics.
  • Integration of epiomics and interactomics within the omics hierarchy.
  • Review of technologies for omics data interrogation.

Main Results:

  • Hierarchical relationships between different omics layers are established.
  • Current technologies for omics analysis are reviewed.
  • Emerging fields like redoxomics are highlighted as promising for understanding cellular states.

Conclusions:

  • Translating omics information for disease control requires a strategic approach.
  • Minimal cell perturbation is a key consideration for future omics applications.
  • Redoxomics offers a novel perspective on cellular decision-making in health and disease.