Optimization of antidote stocking, availability, and administration practices for a large multihospital organization

Area of Science:

• Pharmacy
• Healthcare Management
• Patient Safety

Background:

• Inadequate hospital antidote inventory is a global challenge.
• Factors contributing to this issue include high costs, lack of emphasis on importance, variable standards, hospital size, and drug availability.
• This impacts patient safety and timely treatment.

Purpose of the Study:

• To implement and evaluate process and policy changes for antidote stocking, availability tracking, and administration.
• To ensure appropriate inventory levels and enhance patient safety within a large health system.
• To address the international issue of inadequate hospital antidote inventory.

Main Methods:

• A 12-month process and policy implementation across 11 acute care hospitals.
• Data capture of institution-specific antidote inventory and usage.
• Determination of minimum par levels based on expert recommendations for pharmacies and automated dispensing machines.
• Modification of order sets, statements, and smart pump drug libraries for standardized practices.
• System-wide electronic health record transition.

Main Results:

• Optimization opportunities were identified through data analysis.
• Standardized minimum par levels were established for emergency departments and central pharmacies.
• Changes facilitated standardized practices and aimed to minimize safety errors.
• Ensured availability of antidotes for at least one 100-kg patient based on acquisition acuity.

Conclusions:

• Institutions should identify areas for improvement in antidote inventory and management.
• Implementing similar processes for stocking, sharing, and delivery is feasible and necessary.
• These strategies can mitigate issues with drug acquisition and timely administration.
• Improving antidote management is crucial for patient safety and healthcare delivery.