Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Poly(lactide-co-glycolide) nanoparticles (PLGA NPs) are widely used drug carriers.
• Traditional PLGA NPs face challenges like drug leakage and poor in vivo distribution.
• Cell membrane (CM) camouflage offers a solution to enhance NP performance.

Purpose of the Study:

• To review the development of CM-camouflaged PLGA NPs (CM@PLGA NPs).
• To discuss CM engineering strategies and their impact on NP functionality.
• To highlight therapeutic and diagnostic applications of CM@PLGA NPs.

Main Methods:

• Description of commonly used anucleate and eukaryotic CMs for camouflage.
• Discussion of CM engineering strategies: genetic, nongenetic, and hybrid membrane technologies.
• Review of therapeutic and diagnostic applications across various diseases.

Main Results:

• CM camouflage enhances PLGA NPs by imparting cell-like properties.
• Engineered CMs enrich CM@PLGA NPs for diverse therapeutic purposes.
• CM@PLGA NPs show promise in treating cancer, cardiovascular diseases, viral infections, and eye diseases.

Conclusions:

• CM@PLGA NPs represent a significant advancement over traditional PLGA carriers.
• CM engineering strategies are crucial for unlocking the full therapeutic potential of these biomimetic systems.
• Further research and clinical translation are expected for CM@PLGA NPs in medicine.