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Related Experiment Video

Updated: Sep 4, 2025

Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice
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Treatable traits in the NOVELTY study.

Alvar Agustí1,2,3,4, Eleni Rapsomaniki5, Richard Beasley6

  • 1Càtedra Salut Respiratoria, Universitat Barcelona, Barcelona, Spain.

Respirology (Carlton, Vic.)
|July 21, 2022
PubMed
Summary

Treatable traits (TTs) in asthma and COPD vary widely and are recognized by clinicians for diagnosis and severity grading. This study provides the most detailed real-world characterization of TTs in airway diseases to date.

Keywords:
COPDairwaysallergyasthmabronchitischronic obstructive pulmonary diseaseemphysemasmoking

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Area of Science:

  • Respiratory Medicine
  • Pulmonology
  • Clinical Epidemiology

Background:

  • Asthma and COPD are complex respiratory diseases requiring personalized management strategies.
  • The role of treatable traits (TTs) in real-world clinical practice for these conditions is not well understood.
  • This study investigates the prevalence and relationship of TTs to diagnosis and severity in asthma, COPD, and asthma+COPD.

Purpose of the Study:

  • To determine the prevalence of specific treatable traits (TTs) in patients diagnosed with asthma, COPD, or both.
  • To assess the relationship between the presence/absence of TTs and the physician-assigned diagnosis and disease severity.
  • To characterize TTs in a large, global, real-world cohort of patients with airway diseases.

Main Methods:

  • Analysis of 30 frequently occurring TTs from the NOVELTY study cohort (N=11,226).
  • Data collected systematically in primary care and specialized centers globally.
  • Patients categorized into asthma (52.8%), COPD (34.7%), or asthma+COPD (12.4%) groups.

Main Results:

  • The mean number of TTs per patient varied significantly across diagnoses (4.6 in asthma, 5.4 in COPD, 6.4 in asthma+COPD; p<0.0001).
  • TT prevalence showed differences between primary and specialized care settings, but not major global geographical variations.
  • While some TTs were diagnosis-specific, many were not, and their patterns informed clinical diagnosis and severity assessment.

Conclusions:

  • This study offers the most extensive and granular real-world characterization of TTs in patients with airway diseases to date.
  • The findings highlight the complexity of TTs and their recognized role in clinical decision-making for asthma and COPD.
  • Understanding TT prevalence and patterns is crucial for advancing personalized management in respiratory medicine.