Silver nitrate irrigation for hematuria from sickle cell hemoglobinopathy

Three patients with significant unilateral, gross hematuria owing to sickle cell hemoglobinopathy were treated successfully with retrograde instillation of 1 per cent silver nitrate. There have been no recurrences of gross hematuria during 11 to 15 months of followup. With standard endoscopic evaluation, verification of the etiology of hematuria from sickle hemoglobinopathy and effective treatment can be accomplished quickly and safely.