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Published on: October 12, 2017
Association of Physical Activity With Bioactive Lipids and Cardiovascular Events
Rosangela A Hoshi1,2, Yanyan Liu1,2, Heike Luttmann-Gibson1,2,3
1Center for Lipid Metabolomics, Division of Preventive Medicine, Division of Cardiovascular Medicine (R.A.H., Y.L., H.L.-G., P.M.R., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background:
To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations.
Methods:
PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www.
Clinicaltrials:
gov; Unique identifier: NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION: URL: https://www.
Clinicaltrials:
gov; Unique identifier: NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation).
Results:
We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs: 12,13-diHOME, 9,10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD.
Conclusions:
We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.
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