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Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis
Christine Klykken1,2, Lauris Boissonnot1, Anne Katrine Reed3
1Aqua Kompetanse AS, Flatanger, Norway.
Journal of Fish Diseases
|July 21, 2022
Summary
Nephrocalcinosis in Atlantic salmon causes significant gene expression changes, including reduced metabolism and increased inflammation, severely impacting fish health and survival.
Area of Science:
- Aquatic animal health
- Fish physiology
- Molecular biology
Background:
- Nephrocalcinosis is prevalent in farmed Atlantic salmon.
- The physiological impacts of nephrocalcinosis on salmon are poorly understood.
Purpose of the Study:
- To investigate the molecular and physiological consequences of nephrocalcinosis in Atlantic salmon.
- To identify gene expression changes associated with severe chronic nephrocalcinosis.
Main Methods:
- Transcriptome analysis of kidney tissue from healthy and nephrocalcinosis-affected Atlantic salmon smolts.
- Differential gene expression profiling.
Main Results:
- Significant alterations in gene expression patterns were observed in salmon with nephrocalcinosis.
- Key changes included downregulation of metabolism and energy production genes.
- Upregulation of genes related to tissue repair, function maintenance, and inflammatory responses was noted.
Conclusions:
- Severe nephrocalcinosis induces extensive kidney tissue damage and profound gene regulatory responses in Atlantic salmon.
- These changes likely have critical implications for salmon survival and overall health in aquaculture settings.
