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Related Concept Videos

Tissue Membranes01:27

Tissue Membranes

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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial...
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Introduction to Fibroblasts01:09

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Related Experiment Video

Updated: Sep 4, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

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Self-Healing Fibrous Membranes.

Miaomiao Zhu1,2, Jianyong Yu1,3, Zhaoling Li1,4,3

  • 1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Angewandte Chemie (International Ed. in English)
|July 21, 2022
PubMed
Summary
This summary is machine-generated.

This review explores self-healing fibrous membranes (SFMs), advanced materials combining porosity and self-repair. It details their mechanisms, design, and preparation, aiming for highly efficient and stable SFMs.

Keywords:
Mechanical Property RecoveryMembranesSelf-Healing Fibrous MembranesSelf-Healing MechanismStructure Design

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Murine Dermal Fibroblast Isolation by FACS
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Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Science

Background:

  • Self-healing materials mimic biological systems, offering autonomous repair capabilities.
  • Self-healing fibrous membranes (SFMs) integrate porous structures with self-healing properties.
  • Developing SFMs presents unique challenges due to complex microstructures and healing mechanisms.

Purpose of the Study:

  • To review the state-of-the-art in self-healing fibrous membranes (SFMs).
  • To elucidate the self-healing mechanisms, design principles, and preparation strategies for SFMs.
  • To identify current challenges and future directions for developing advanced SFMs.

Main Methods:

  • Literature review and analysis of existing research on SFMs.
  • Discussion of various self-healing mechanisms applicable to fibrous membranes.
  • Examination of design principles and fabrication techniques for SFMs.

Main Results:

  • SFMs offer a promising platform for materials with both porosity and autonomous repair.
  • Complex healing mechanisms and microstructures are key considerations in SFM development.
  • Current research focuses on optimizing SFM performance and stability.

Conclusions:

  • SFMs represent a significant advancement in self-healing materials.
  • Further research is needed to overcome challenges in SFM preparation and healing efficiency.
  • The ultimate goal is to achieve highly efficient and superstable self-healing fibrous membranes.