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Evolution gone wrong: Enteric serotonergic neurons and colorectal cancer
1Department of Pathology and Cell Biology, Columbia University Vagelos College of Physician and Surgeons, 630 West 168(th) Street, New York, NY 10032, USA.
Neuron
|July 21, 2022
Summary
Enteric serotonin neurons surprisingly drive colorectal cancer stem cell proliferation. This finding highlights a novel therapeutic target for colorectal cancer treatment.
Area of Science:
- Neuroscience
- Gastroenterology
- Oncology
Background:
- Serotonin is a key signaling molecule with diverse physiological roles.
- The enteric nervous system (ENS) regulates gastrointestinal functions.
- Colorectal cancer (CRC) stem cells are crucial for tumor growth and recurrence.
Purpose of the Study:
- To investigate the role of enteric serotonin in colorectal cancer stem cell proliferation.
- To identify the source of serotonin driving CRC stem cell growth.
Main Methods:
- Utilized mouse models of colorectal cancer.
- Employed genetic and pharmacological tools to manipulate enteric serotonin.
- Assessed cancer stem cell proliferation and tumor growth.
Main Results:
- Enteric serotonin neurons, despite their small numbers, significantly promote CRC stem cell proliferation.
- Inhibition of enteric serotonin signaling reduced cancer stem cell growth and tumor burden.
- Serotonin released by enteric neurons directly impacts CRC stem cells.
Conclusions:
- Enteric serotonin is a critical driver of colorectal cancer stem cell proliferation.
- Targeting enteric serotonin signaling represents a potential therapeutic strategy for CRC.
- This study reveals a novel link between the nervous system and cancer progression.
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