Related Experiment Video

Updated: Sep 4, 2025

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.3K

Advancing the prevention and treatment of HIV in children: priorities for research and development

Martina Penazzato1, Claire L Townsend1, Nadia A Sam-Agudu2

  • 1HIV Department, WHO, Geneva, Switzerland.

The Lancet. HIV
|July 21, 2022
PubMed

Insights

Developing safe and effective pediatric HIV treatments is vital. The PADO-HIV group prioritized new drugs and formulations to accelerate access for children globally.

Area of Science:

  • Pediatric infectious diseases
  • HIV/AIDS research
  • Pharmaceutical development

Background:

  • Effective pediatric antiretroviral (ARV) drug formulations are essential for HIV treatment and prevention in children.
  • The World Health Organization's Paediatric Drug Optimization for HIV (PADO-HIV) group convenes experts to address research gaps.
  • Low- and middle-income countries face particular challenges in accessing pediatric HIV medications.

Purpose of the Study:

  • To identify priority HIV drugs and formulations for pediatric use.
  • To define research gaps in the development of new HIV treatments for children.
  • To guide funders, drug developers, and researchers in accelerating access to optimal pediatric HIV therapies.

Main Methods:

  • The PADO-HIV 5 meeting (September 27–October 15, 2021) convened global stakeholders and experts.
  • Evaluation of existing and novel ARV drug classes, including oral and parenteral long-acting formulations.
  • Focused sessions on neonatal HIV treatment and innovative drug delivery technologies were conducted.

Main Results:

  • A comprehensive list of medium-term and long-term priorities for pediatric HIV drug development was generated.
  • Specific research questions were defined to address identified knowledge and development gaps.
  • Key areas for future research and investment were highlighted.

Conclusions:

  • The PADO-HIV 5 meeting established critical priorities for advancing pediatric HIV treatment and prevention.
  • The defined priorities and research questions aim to accelerate the development and accessibility of optimal HIV drugs for children.
  • This strategic guidance is crucial for ensuring children receive the most effective HIV therapies available.

More Related Videos

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

18.6K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

16.8K

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
406
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.6K
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
13.0K