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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
Maciej Krzeszewski1, Sylwia Modrzycka2, Manon H E Bousquet3
1Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Organic Letters
|July 21, 2022
Abstract:
The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.

