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Core outcome set for peripheral regional anesthesia research: a systematic review and Delphi study
Jeremy Hill1, Toby Ashken2, Simeon West2
1Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK jeremy.hill1@nhs.net.
Regional Anesthesia and Pain Medicine
|July 21, 2022
Summary
Researchers developed a core outcome set for regional anesthesia research to standardize outcome measurement. This consensus-driven set aims to improve data relevance and reduce bias in future studies.
Area of Science:
- Anesthesiology
- Clinical Research Methodology
Background:
- Significant heterogeneity exists in outcome measures utilized within regional anesthesia research.
- Lack of standardized outcomes hinders comparability and meta-analysis of regional anesthesia studies.
Purpose of the Study:
- To establish a core outcome set for regional anesthesia research through international expert consensus.
- To standardize outcome measurement in regional anesthesia to enhance research quality and data synthesis.
Main Methods:
- A systematic literature review (2015-2019) identified 224 potential outcomes.
- A three-round modified Delphi process involving 21 international regional anesthesia experts was conducted.
- A final Delphi survey and video conference refined consensus on 10 core outcomes and 13 parameters.
Main Results:
- The systematic review yielded 224 unique outcomes from 206 papers.
- Ten core outcomes were selected by international regional anesthesia experts.
- Consensus was reached on 13 specific outcome parameters for measurement.
Conclusions:
- The first core outcome set for regional anesthesia, based on international expert consensus, has been established.
- This core set is intended as a minimum standard to improve outcome relevance and reduce reporting bias.
- Adoption of this set may enhance data availability and suitability for meta-analysis in regional anesthesia.
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