Related Experiment Video

Updated: Sep 4, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

472

Association of Blood Viscosity With Mortality Among Patients Hospitalized With COVID-19

Daein Choi1, Ori Waksman2, Aleesha Shaik2

  • 1Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Metabolism and Lipids Unit, Cardiovascular Institute, Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Journal of the American College of Cardiology
|July 21, 2022
PubMed

Insights

Increased whole blood viscosity (WBV) in COVID-19 patients is linked to higher mortality. This finding suggests WBV could be a prognostic tool for COVID-19 outcomes.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease Epidemiology
  • Medical Physiology

Background:

  • COVID-19 is associated with immune dysfunction and abnormal blood rheology, leading to endothelial dysfunction and thrombosis.
  • Whole blood viscosity (WBV) is a validated measure of blood rheology and a predictor of cardiovascular risk.
  • The study investigates the link between WBV and mortality in hospitalized COVID-19 patients.

Purpose of the Study:

  • To determine the association between estimated blood viscosity (eBV) and mortality in hospitalized COVID-19 patients.
  • To assess if eBV can serve as a prognostic indicator for COVID-19 patient outcomes.

Main Methods:

  • Analysis of 5,621 hospitalized COVID-19 patients from February 2020 to November 2021.
  • Calculation of eBV using the Walburn-Schneck model.
  • Multivariate Cox proportional hazards models were employed, adjusting for clinical and demographic factors.

Main Results:

  • Both high-shear and low-shear eBV were significantly associated with increased in-hospital mortality.
  • A 1 centipoise increase in eHSBV correlated with a 36% increase in death risk.
  • Patients in the highest quartile of eHSBV exhibited significantly higher mortality compared to the lowest quartile.

Conclusions:

  • Elevated eBV is a significant predictor of mortality in hospitalized COVID-19 patients.
  • eBV shows potential as an early prognostic biomarker for COVID-19.
  • Therapeutic strategies targeting the reduction of WBV warrant further investigation for improving COVID-19 patient outcomes.
Abstract

Keywords:
COVID-19blood viscositycardiovascular diseasemortalityrheology epidemiology

More Related Videos

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

1.7K
An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices08:44

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

7.3K

Related Concept Videos

Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
3.7K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.1K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
326
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
30
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
290
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
5.1K