Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

237
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
237
Aging01:26

Aging

164
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
164
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

663
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
663
Dementia01:30

Dementia

162
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
162
Interference and Decay01:16

Interference and Decay

199
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
199
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual heterogeneity in neuroimaging markers of functional outcomes in patients with acute ischaemic stroke.

Stroke and vascular neurology·2026
Same author

Lesion network mapping for post-stroke cognitive impairment.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Lesion Network Mapping for Atrial Fibrillation Newly Detected on ECG or Cardiac Monitoring After Stroke.

Journal of the American Heart Association·2025
Same author

Inhibition of Ipsilesional M1 β Oscillations by Contralesional M1 Following Acute Ischemic Stroke: A TMS-EEG Study.

Stroke·2025
Same author

Association Between White Matter Hyperintensity and Cognitive Impairment in Cerebral Small Vessel Disease: The Frequency-dependent Role of Brain Functional Activity.

Journal of integrative neuroscience·2025
Same author

Altered effective connectivity within brain lesioned regions and cognitive impairment after stroke.

Cognitive neurodynamics·2025
Same journal

Association between amygdala subregions and non-motor symptoms in Parkinson's disease: a fixel-based analysis.

Brain imaging and behavior·2026
Same journal

Normalization method for relative cerebral blood flow influences sex and cognitive status effects in nondemented older adults.

Brain imaging and behavior·2026
Same journal

Lack of association of the 5-HTTLPR polymorphism and brain serotonin transporter or receptor in healthy individuals: bayesian and frequentist meta-analyses.

Brain imaging and behavior·2026
Same journal

Prediction modeling in transdiagnostic risk: results from the PROCAN study.

Brain imaging and behavior·2026
Same journal

Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.

Brain imaging and behavior·2026
Same journal

Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.

Brain imaging and behavior·2026
See all related articles

Related Experiment Video

Updated: Sep 4, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.8K

Cognitive decline is associated with frequency-specific resting state functional changes in normal aging.

Dongqiong Fan1, Tao Liu2, Jiyang Jiang3

  • 1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Brain Imaging and Behavior
|July 21, 2022
PubMed
Summary
This summary is machine-generated.

Investigating resting-state brain activity across multiple frequency bands reveals insights into cognitive aging. Changes in amplitude of low-frequency fluctuations (ALFF) correlate with cognitive function, aiding understanding of normal cognitive aging.

Keywords:
AgingAmplitude of low-frequency fluctuations (ALFF)Global cognitionResting state

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

32.7K

Related Experiment Videos

Last Updated: Sep 4, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.8K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

32.7K

Area of Science:

  • Neuroscience
  • Cognitive Aging Research
  • Functional Neuroimaging

Background:

  • Resting-state brain activity, specifically low-frequency fluctuations, is crucial for understanding cognitive aging.
  • Amplitude of Low-Frequency Fluctuations (ALFF) in functional MRI (fMRI) provides a measure of local brain activity.
  • Previous research has primarily focused on a single frequency band, potentially overlooking complex aging-related changes.

Purpose of the Study:

  • To explore the characteristics of ALFF across different frequency bands (typical, slow-5, slow-4, slow-3, slow-2) in cognitively normal older adults.
  • To investigate how these ALFF characteristics change over a four-year period.
  • To determine the association between ALFF changes and cognitive function in aging.

Main Methods:

  • Longitudinal study of 37 cognitively normal older adults with baseline and 4-year follow-up MRI scans and neuropsychological tests.
  • Calculation and analysis of ALFF in five distinct frequency bands from fMRI data.
  • Statistical analyses including two-way ANOVA, paired-sample t-tests, and partial correlation to assess time-frequency interactions, within-group changes, and ALFF-cognition associations.

Main Results:

  • Significant time × frequency interaction effects on ALFF were observed in brain regions including the inferior frontal gyrus, superior frontal gyrus, thalamus, and putamen.
  • Widespread ALFF reductions were noted across all five bands, predominantly in the right hemisphere and posterior cerebellum.
  • Increased ALFF was localized to the cerebellum and left hemisphere, with frequency-specific patterns.
  • ALFF changes demonstrated frequency-specific correlations with cognitive function changes over time.

Conclusions:

  • Cognitive aging involves complex, frequency-dependent alterations in local brain activity.
  • Investigating ALFF across multiple frequency bands is essential for a comprehensive understanding of normal cognitive aging.
  • Frequency-specific ALFF changes are associated with cognitive trajectories, offering potential biomarkers for cognitive aging.