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Long non‑coding RNA PART1: dual role in cancer
Rui Ran1,2, Chao-Yang Gong1,2, Zhi-Qiang Wang1,2
1Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730000, People's Republic of China.
Human Cell
|July 21, 2022
Summary
Prostate androgen-regulated transcript 1 (PART1) long non-coding RNA has a dual role in human cancers, acting as both an oncogene and tumor suppressor. Understanding PART1
Area of Science:
- * Molecular biology
- * Oncology
- * Genetics
Background:
- * Long non-coding RNAs (lncRNAs) are crucial regulators in cellular processes and disease.
- * lncRNAs function as oncogenes or tumor suppressors in human cancers.
- * Prostate androgen-regulated transcript 1 (PART1) is implicated in tumorigenesis.
Purpose of the Study:
- * To review the biological functions of PART1 in various human cancers.
- * To elucidate the regulatory mechanisms of PART1 in cancer development.
- * To explore the clinical significance of PART1 as a biomarker and therapeutic target.
Main Methods:
- * Literature review of studies on PART1 in cancer.
- * Analysis of PART1 expression patterns in different tumor types.
- * Examination of documented molecular mechanisms underlying PART1's function.
Main Results:
- * PART1 exhibits context-dependent roles, acting as an oncogene or tumor suppressor.
- * Upregulated PART1 promotes tumors in liver, prostate, and lung cancers.
- * Downregulated PART1 inhibits tumors in esophageal squamous cell carcinoma and glioma.
- * PART1 influences cell proliferation, apoptosis, invasion, and metastasis.
Conclusions:
- * PART1 demonstrates a dual role in cancer, highlighting its complex involvement.
- * PART1's functions are mediated through diverse molecular pathways.
- * PART1 represents a potential diagnostic biomarker and therapeutic target in oncology.
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