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Long non‑coding RNA PART1: dual role in cancer

Rui Ran1,2, Chao-Yang Gong1,2, Zhi-Qiang Wang1,2

  • 1Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730000, People's Republic of China.

Human Cell
|July 21, 2022
PubMed

Insights

Prostate androgen-regulated transcript 1 (PART1) long non-coding RNA has a dual role in human cancers, acting as both an oncogene and tumor suppressor. Understanding PART1

Area of Science:

  • * Molecular biology
  • * Oncology
  • * Genetics

Background:

  • * Long non-coding RNAs (lncRNAs) are crucial regulators in cellular processes and disease.
  • * lncRNAs function as oncogenes or tumor suppressors in human cancers.
  • * Prostate androgen-regulated transcript 1 (PART1) is implicated in tumorigenesis.

Purpose of the Study:

  • * To review the biological functions of PART1 in various human cancers.
  • * To elucidate the regulatory mechanisms of PART1 in cancer development.
  • * To explore the clinical significance of PART1 as a biomarker and therapeutic target.

Main Methods:

  • * Literature review of studies on PART1 in cancer.
  • * Analysis of PART1 expression patterns in different tumor types.
  • * Examination of documented molecular mechanisms underlying PART1's function.

Main Results:

  • * PART1 exhibits context-dependent roles, acting as an oncogene or tumor suppressor.
  • * Upregulated PART1 promotes tumors in liver, prostate, and lung cancers.
  • * Downregulated PART1 inhibits tumors in esophageal squamous cell carcinoma and glioma.
  • * PART1 influences cell proliferation, apoptosis, invasion, and metastasis.

Conclusions:

  • * PART1 demonstrates a dual role in cancer, highlighting its complex involvement.
  • * PART1's functions are mediated through diverse molecular pathways.
  • * PART1 represents a potential diagnostic biomarker and therapeutic target in oncology.
Keywords:
CancerMechanismsPART1lncRNA

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