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Related Concept Videos

Amnesia01:13

Amnesia

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Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
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Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

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Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Dissociative Amnesia01:21

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Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
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The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
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Glymphatic System Function in Patients with Transient Global Amnesia.

Dong Ah Lee1, Bong Soo Park2, Sihyung Park2

  • 1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, 48108 Busan, Republic of Korea.

Journal of Integrative Neuroscience
|July 22, 2022
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Summary

Glymphatic system function did not differ between patients with transient global amnesia (TGA) and healthy individuals. However, the glymphatic system

Keywords:
diffusion tensor imagingglymphatic systemtransient global amnesia

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Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Transient global amnesia (TGA) is a neurological condition characterized by sudden, temporary memory loss.
  • The glymphatic system is crucial for waste clearance in the brain, and its dysfunction is implicated in various neurological disorders.
  • Understanding glymphatic system function in TGA is essential for elucidating its pathophysiology.

Purpose of the Study:

  • To investigate glymphatic system function in patients diagnosed with transient global amnesia (TGA).
  • To analyze potential differences in glymphatic function related to the recurrence of TGA events.
  • To compare glymphatic system function between TGA patients and age-matched healthy controls.

Main Methods:

  • Retrospective enrollment of 72 TGA patients and 53 healthy controls.
  • Acquisition of diffusion tensor imaging (DTI) data using a 3T scanner for all participants.
  • Assessment of glymphatic system function via diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) and comparison of the ALPS index.

Main Results:

  • No significant difference in the ALPS index was observed between TGA patients and healthy controls (p = 0.436).
  • The ALPS index was significantly higher in TGA patients who experienced recurrent events compared to those with a single event (p = 0.049).
  • This suggests glymphatic system function may vary based on TGA recurrence.

Conclusions:

  • This study is the first to utilize the DTI-ALPS method to assess glymphatic system function in TGA patients.
  • Glymphatic system function does not appear to be globally impaired in TGA patients compared to healthy controls.
  • Recurrence of TGA events may be associated with altered glymphatic system function, warranting further investigation.