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Published on: February 16, 2022
The Chemistry of HNO: Mechanisms and Reaction Kinetics
Radosław Michalski1, Renata Smulik-Izydorczyk1, Jakub Pięta1
1Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland.
Abstract:
Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.
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