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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
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Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life
Marina Sánchez-Agesta1, Cristina Rabasco1, María J Soler2
1Department of Nephrology, Hospital Universitario Reina Sofía, Córdoba, Spain.
Frontiers in Medicine
|July 22, 2022
Summary
Severe anti-glomerular basement membrane (anti-GBM) disease has a poor renal prognosis, even with plasma exchange and immunosuppression. High creatinine and crescent levels predict end-stage kidney disease (ESKD) in these patients.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Anti-glomerular basement membrane (anti-GBM) disease is a severe autoimmune condition.
- Limited therapeutic options exist, primarily plasma exchange and immunosuppressive agents.
- Predicting outcomes in anti-GBM disease with renal involvement is crucial.
Purpose of the Study:
- To analyze clinical and pathological features predicting end-stage kidney disease (ESKD) evolution.
- To evaluate kidney survival in a real-life cohort of anti-GBM disease patients.
- To identify predictors of poor renal outcomes in anti-GBM disease.
Main Methods:
- Retrospective multicentre observational study (1999-2019).
- Inclusion of 72 patients with biopsy-proven anti-GBM disease.
- Evaluation of clinical and histological variables for ESKD progression.
Main Results:
- High admission creatinine (> 4.7 mg/dL) and >50% crescents predicted worse kidney survival.
- Dialysis dependence and high creatinine were independent predictors of ESKD.
- Kidney survival at 1 and 2 years was 13.5% and 11%, respectively.
Conclusions:
- Severe anti-GBM disease carries a devastating renal prognosis despite current treatments.
- Urgent need for novel therapeutic strategies for anti-GBM disease.
- High creatinine and crescent burden indicate a critical need for intervention.
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