Lipoprotein(a) in Cardiovascular Diseases: Insight From a Bibliometric Study

Area of Science:

• Cardiovascular Research
• Biochemistry
• Medical Informatics

Background:

• Lipoprotein(a) [Lp(a)] is a genetically determined lipoprotein linked to premature cardiovascular disease.
• Its role in atherosclerotic cardiovascular disease and calcific aortic valve stenosis is increasingly recognized.
• Emerging therapies, including antisense oligonucleotides and RNA interference, target Lp(a).

Purpose of the Study:

• To conduct a bibliometric analysis of the Lp(a) research landscape.
• To map the distribution, dynamics, and influential publications in Lp(a) research.
• To identify key research themes and emerging trends in Lp(a) studies.

Main Methods:

• Bibliometric descriptive analysis using Scopus.
• Literature mapping and identification of prolific sources, institutions, and countries.
• Analysis of historical and influential papers using RPYS and CRExplorer software.

Main Results:

• Identified key research areas including inflammation, atherosclerosis, cardiovascular risk, and treatment options.
• Highlighted the growing focus on Lp(a) in calcific aortic valve stenosis and post-menopausal hormonal changes.
• Provided a comprehensive overview of the global research output and collaboration patterns.

Conclusions:

• The study offers a broad perspective on Lp(a) research, emphasizing its clinical significance.
• It highlights the potential of emerging pharmacological interventions for Lp(a)-related conditions.
• This analysis aids in understanding the translation of Lp(a) research into clinical practice.