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Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino
Nawal M Al Malahi1, Masaa M Al Jumaily2, Elham A S Al-Shaibani2
1Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Abstract:
The objective of this research was to look at how the pesticide lambda-cyhalothrin (LCT) affected the liver, kidney, testis, and ovary of albino mice; and on morphological and skeletal features of the newborn of treated females. The study also aimed to test the ameliorative effects of L-carnitine (LC) against (LCT). Five sets of mice were created, Group 1 acted as the control, while Group 2 received a high dose of LCT, Group 3 received a high dose of LCT + LC, Group 4 received a low dose of LCT that was a residue of in khat (Qat), and Group 5 received a low dose of LCT + LC. The findings revealed that the treated groups' body weights were reduced significantly, whereas the absolute and relative weights of the liver in all groups were statistically decreased insignificantly. There were histopathological changes in the tissues in groups 2 and 4. While the tissues of the ovary and testis showed recovery in groups 3 and 5. When compared to the control group, the values of the seminiferous tubules parameters were statistically significant in the 3 and 5 groups. The newborn had a high dose of pesticides and showed some malformations in the skeleton. However, in group 3 the skeletal malformation was minimized and in-group 5 the skeleton malformations had completely disappeared. It could be concluded that LCT is highly harmful to mouse tissues and caused neonatal malformations, whereas LC has a marked protective effect against LCT.
Insights
Lambda-cyhalothrin (LCT) pesticide exposure harms albino mice liver, kidney, and reproductive tissues, causing skeletal malformations in newborns. L-carnitine (LC) significantly mitigates these harmful effects.
Area of Science:
- Toxicology
- Reproductive Biology
- Developmental Biology
Background:
- Pesticide exposure, specifically lambda-cyhalothrin (LCT), poses risks to mammalian health.
- Understanding the toxicological impact of LCT on vital organs and reproductive systems is crucial.
- Investigating potential protective agents against pesticide toxicity is an important area of research.
Purpose of the Study:
- To evaluate the effects of lambda-cyhalothrin (LCT) on the liver, kidney, testis, and ovary of albino mice.
- To assess the impact of LCT on the morphological and skeletal development of newborn mice from treated females.
- To determine the protective efficacy of L-carnitine (LC) against LCT-induced toxicity.
Main Methods:
- Albino mice were divided into five groups: control, high-dose LCT, high-dose LCT + L-carnitine (LC), low-dose LCT (khat residue), and low-dose LCT + LC.
- Organ weights, histopathological changes in liver, kidney, ovary, and testis were analyzed.
- Reproductive parameters, including seminiferous tubule values, were assessed.
- Skeletal and morphological features of newborn mice were examined.
Main Results:
- LCT exposure led to significant reductions in body weight and non-significant decreases in liver weight.
- Histopathological damage was observed in liver and kidney tissues following LCT exposure.
- Ovarian and testicular tissues showed signs of recovery in groups treated with L-carnitine.
- Newborns from LCT-exposed mothers exhibited skeletal malformations, which were reduced or eliminated with LC co-administration.
Conclusions:
- Lambda-cyhalothrin (LCT) is demonstrably harmful to mouse tissues and reproductive health.
- LCT exposure can cause significant skeletal malformations in offspring.
- L-carnitine (LC) exhibits a notable protective effect against the adverse impacts of LCT.
