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Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Emerging Role of Non-Coding RNAs in Senescence
Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Frontiers in Cell and Developmental Biology
|July 22, 2022
Summary
Cellular senescence, a defense mechanism, can limit tumors but also contributes to diseases. Non-coding RNAs, including long non-coding RNAs, microRNAs, and circular RNAs, play significant roles in this process.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Cellular senescence is a state of irreversible cell cycle arrest.
- It acts as a tumor suppressor mechanism and a response to cellular damage.
- Dysregulation of senescence is implicated in aging and various diseases, including fibrosis, diabetes, and sarcopenia.
Purpose of the Study:
- To review the current literature on the role of non-coding RNAs in cellular senescence.
- To highlight the involvement of long non-coding RNAs, microRNAs, and circular RNAs in senescence.
Main Methods:
- Literature review of recent studies on non-coding RNAs and cellular senescence.
- Analysis of the impact of different non-coding RNA classes on senescence pathways.
Main Results:
- Non-coding RNAs, including lncRNAs, miRNAs, and circRNAs, are increasingly recognized for their regulatory roles in cellular senescence.
- These molecules influence senescence induction, maintenance, and functional outcomes.
- Specific non-coding RNAs have been linked to both protective and detrimental aspects of senescence in disease.
Conclusions:
- Non-coding RNAs are critical regulators of cellular senescence.
- Targeting these non-coding RNAs presents potential therapeutic strategies for senescence-associated diseases.
- Further research is needed to fully elucidate the complex roles of non-coding RNAs in senescence.
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