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Updated: Sep 4, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.7K

Emerging Role of Non-Coding RNAs in Senescence

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Cell and Developmental Biology
|July 22, 2022
PubMed

Insights

Cellular senescence, a defense mechanism, can limit tumors but also contributes to diseases. Non-coding RNAs, including long non-coding RNAs, microRNAs, and circular RNAs, play significant roles in this process.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cellular senescence is a state of irreversible cell cycle arrest.
  • It acts as a tumor suppressor mechanism and a response to cellular damage.
  • Dysregulation of senescence is implicated in aging and various diseases, including fibrosis, diabetes, and sarcopenia.

Purpose of the Study:

  • To review the current literature on the role of non-coding RNAs in cellular senescence.
  • To highlight the involvement of long non-coding RNAs, microRNAs, and circular RNAs in senescence.

Main Methods:

  • Literature review of recent studies on non-coding RNAs and cellular senescence.
  • Analysis of the impact of different non-coding RNA classes on senescence pathways.

Main Results:

  • Non-coding RNAs, including lncRNAs, miRNAs, and circRNAs, are increasingly recognized for their regulatory roles in cellular senescence.
  • These molecules influence senescence induction, maintenance, and functional outcomes.
  • Specific non-coding RNAs have been linked to both protective and detrimental aspects of senescence in disease.

Conclusions:

  • Non-coding RNAs are critical regulators of cellular senescence.
  • Targeting these non-coding RNAs presents potential therapeutic strategies for senescence-associated diseases.
  • Further research is needed to fully elucidate the complex roles of non-coding RNAs in senescence.
Keywords:
biomarkerepigeneticsexpressionlncRNAmiRNAsenescence

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