Related Experiment Video

Updated: Sep 4, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

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Identification of Key Carcinogenic Genes in Colon Adenocarcinoma

Yangbin Dai1, Zhenjian Jiang1, Yanru Qiu1

  • 1Department of Medical Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

Iranian Journal of Public Health
|July 22, 2022
PubMed
Abstract

Insights

This study identifies key carcinogenic genes and microRNAs involved in colon adenocarcinoma (COAD) development. Findings reveal potential therapeutic targets and molecular mechanisms for COAD treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Colon adenocarcinoma (COAD) is a significant health concern.
  • Understanding the molecular drivers of COAD is crucial for effective treatment.

Purpose of the Study:

  • To identify carcinogenic genes and microRNAs associated with COAD development.
  • To explore the molecular mechanisms and potential therapeutic targets in COAD.

Main Methods:

  • Downloaded COAD gene expression profiles from TCGA.
  • Identified differentially expressed genes (DEGs) and analyzed GO and KEGG pathways.
  • Constructed miRNA-target networks and analyzed gene associations with overall survival and immune infiltration.

Main Results:

  • Identified numerous up- and down-regulated mRNAs and miRNAs in COAD.
  • Discovered enriched GO terms and KEGG pathways.
  • Found specific miRNA-mRNA pairs, including HOXC13, FOXL2NB, ALOXE3, and ZIC2, linked to poorer overall survival and immune cell infiltration.

Conclusions:

  • The identified risk genes and interaction networks enhance understanding of COAD molecular mechanisms.
  • These findings suggest potential therapeutic targets for clinical treatment of COAD.
Keywords:
Bioinformatics analysisCarcinogenic geneColon cancerDatabase

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