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Updated: Sep 4, 2025

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
[Mental health consequences of isolation of patients with COVID-19.]
Elena Navas1, Merce López1,2, Miguel Ángel Muñoz1,3,4
1Unidad de Apoyo a la Investigación en Atención Primaria de Salud en Barcelona, Instituto Catalán de la Salud, Instituto Universitario de Investigación en Atención Primaria Jordi Gol (IDIAP Jordi Gol i Gurina). Barcelona. España.
Objective:
The COVID-19 pandemic has had a negative effect on the mental health on the population. It is unknown if the different types of patient isolation affect them equally. The objective of the study was to determine if the effect on the psychological discomfort caused by the isolation of the population with COVID-19 in a hotel supervised by health professionals was different compared with those who were isolated at home.
Methods:
Patients diagnosed with COVID-19 during the first pandemic wave in Barcelona, consecutively selected from the Primary Care lists. A telephone survey was carried out to collect information about mental health in patients who were isolated in a hotel compared to those isolated at their homes. Descriptive statistics were performed and the study variables were analyzed using mean and standard deviation, count (percentage), Chi-square test, and Student's t-test. Logistic regression models were carried out selecting frustration and anger/irritability as response variables.
Results:
Of the 89 patients included, 45 (50.6%) were isolated at their homes and 44 (49.4%) at the hotel. Frustration was identified in 48.3% and irritability in 29.2% of the most patients. Most of those who presented frustration were between 45 and 65 years old, while 50% of those who felt irritability were younger. Multivariate models confirmed that patients isolated at home showed a higher risk of frustration (Odds ratio 4,12; 95% Confidence interval 1,60-11,49) and irritability (Odds ratio 3,81; 95% Confidence interval 1,32-12,10), respectively.
Conclusions:
Patients isolated at home show a higher risk of presenting feelings of frustration and irritability than isolated patients in supervised hotels.
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