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Updated: Sep 4, 2025
08:42
Assessment of Social Cognition in Non-human Primates Using a Network of Computerized Automated Learning Device ALDM Test Systems
Published on: May 5, 2015
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Cognition in the course of ALS-a meta-analysis
Julia Finsel1, Ingo Uttner1, Cynthia R Vázquez Medrano1
1Department of Neurology, Ulm University, Ulm, Germany and.
Summary
Cognitive impairments are common in Amyotrophic Lateral Sclerosis (ALS) patients from the disease onset. However, these cognitive deficits appear stable over time, suggesting they may be an early trait of the disease.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease.
- Cognitive impairment is frequently observed in ALS patients.
- Understanding the trajectory and predictors of cognitive changes is crucial for patient care.
Approach:
- A comprehensive meta-analysis of cross-sectional and longitudinal studies was performed.
- Searches were conducted in PubMed and Web of Science databases.
- Meta-analyses and meta-regressions were used for cross-sectional data, while longitudinal data were analyzed descriptively.
Key Points:
- ALS patients (PALS) exhibit cognitive impairments across most domains, excluding verbal IQ.
- Cognitive performance in PALS remains largely stable in both cross-sectional and longitudinal studies.
- Age and depressiveness were identified as factors influencing visuospatial functioning and attention, respectively.
Conclusions:
- Cognitive deficits are present early in the course of ALS.
- Limited evidence suggests significant cognitive decline over time in PALS.
- Early-onset cognitive impairment in ALS may represent a disease trait rather than progressive deterioration.
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