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Effect of vitamin D on endothelial and ventricular function in chronic heart failure patients: A prospective,

Jong Shin Woo1, Yeongmin Woo2, Jeong Yoon Jang3

  • 1Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of Korea.

Medicine
|July 22, 2022
PubMed

Insights

Daily vitamin D supplementation (4000 IU) is safe for chronic heart failure patients. While it did not improve endothelial function, it enhanced exercise capacity and reduced left atrial diameter.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Low 25-hydroxyvitamin D (25OHD) levels are prevalent in chronic heart failure (HF) patients.
  • These low levels are linked to increased mortality risk in HF.
  • Vitamin D supplementation's role in HF requires further investigation.

Purpose of the Study:

  • To assess the safety and efficacy of daily oral vitamin D3 (cholecalciferol) supplementation in stable heart failure patients.
  • To evaluate the impact of vitamin D on endothelial and ventricular function.
  • To determine effects on quality of life and exercise capacity.

Main Methods:

  • A multicenter, prospective, randomized, placebo-controlled trial.
  • 73 HF patients with 25OHD < 75 nmol/L received 4000 IU vitamin D or placebo daily for 6 months.
  • Endothelial function (EndoPAT), echocardiographic parameters, and quality of life were primary and secondary endpoints.

Main Results:

  • No adverse events were reported in either the vitamin D or placebo group.
  • Vitamin D supplementation did not significantly improve endothelial function (P = .65).
  • Improvements were observed in blood pressure, 6-minute walking distance, EQ-5D scores, and a reduction in left atrial diameter.

Conclusions:

  • Daily 4000 IU vitamin D supplementation is safe for chronic heart failure patients.
  • This dosage did not enhance endothelial function.
  • Vitamin D treatment improved exercise capacity, symptoms, and cardiac structure (left atrial diameter).
Abstract

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