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Two new cytotoxic tetralin derivatives from Panicum turgidum
Ahmed A Zaki1,2, Yasser A El-Amier3, Ahmed Ashour1,2
1Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Abstract:
Two new tetralin compounds were isolated from the aerial parts of Panicum turgidum Forssk. Their structures were elucidated by comprehensive 1 D and 2 D NMR experiments as well as high resolution ESI mass spectrometry. In addition, these two compounds have been tested for in vitro cytotoxicity against SKOV3 (Ovarian Carcinoma) and BT-549 (Breast Carcinoma). Compound 1 showed good cytotoxic activities against SKOV3 and BT 549 with IC50 value of 5.65 ± 0.31 and 10.3 ± 0.56 µg/mL, respectively.
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