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Post-COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection.
Anna L Funk1, Nathan Kuppermann2,3, Todd A Florin4,5
1Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
JAMA Network Open
|July 22, 2022
Summary
Children with SARS-CoV-2 infection are more likely to develop post-COVID-19 conditions (PCCs) within 90 days. Hospitalization and numerous acute symptoms increase PCC risk in children, necessitating targeted guidance and follow-up.
Area of Science:
- Pediatric Infectious Diseases
- Public Health
- Epidemiology
Background:
- Post-COVID-19 conditions (PCCs) in children remain poorly understood.
- Identifying risk factors for PCCs in pediatric populations is crucial for effective management.
Purpose of the Study:
- To estimate the incidence of PCCs in children 90 days post-SARS-CoV-2 infection.
- To compare PCC rates between SARS-CoV-2-positive and negative children.
- To identify factors associated with PCC development in children.
Main Methods:
- Prospective cohort study in 36 emergency departments across 8 countries.
- Included 1884 SARS-CoV-2-positive children and 1701 SARS-CoV-2-negative controls.
- Follow-up conducted 90 days post-index visit to assess for PCCs.
Main Results:
- 5.8% of SARS-CoV-2-positive children reported PCCs at 90 days.
- Hospitalized children and those with more acute symptoms had higher PCC rates.
- Older children (≥14 years) and those hospitalized for ≥48 hours faced increased risk.
Conclusions:
- SARS-CoV-2 infection is associated with an increased risk of developing PCCs in children.
- Hospitalized children with multiple acute symptoms and older children require focused follow-up.
- Further research and clinical guidance are needed for pediatric PCCs.
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