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Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice.

Rea P Anunciado-Koza1, J Patrizia Stohn1, Arturo Hernandez1,2,3

  • 1Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, United States of America.

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Summary

Loss of the imprinted Mesoderm specific transcript (Mest) gene, also known as paternally expressed gene-1 (Peg1), did not impair social, maternal, or cognitive behaviors in mice. This study found no behavioral deficits in Mest knockout models.

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Area of Science:

  • Genetics
  • Neuroscience
  • Developmental Biology

Background:

  • The imprinted Mesoderm specific transcript (Mest)/paternally expressed gene-1 (Peg1) gene is primarily expressed from the paternal allele.
  • Previous studies reported maternal behavior deficits in a global Mest knockout mouse model (Mesttm1Masu).

Purpose of the Study:

  • To investigate social and maternal behaviors in a novel mouse model of Mest inactivation (Mesttm1.2Rkz).
  • To assess anxiety-like, depression-like, social, and cognitive behaviors in mice with paternal allele Mest inactivation (MestpKO).

Main Methods:

  • Behavioral testing including elevated plus maze, open field trial, marble burying, tail suspension test, three-chamber box test, and novel object recognition test.
  • Analysis of Mest mRNA expression in the hypothalamus and whole brain.
  • Assessment of maternal behaviors in primiparous and virgin female mice.

Main Results:

  • MestpKO mice exhibited no anxiety- or depression-like behaviors.
  • Normal social behaviors and cognitive function were observed in MestpKO mice.
  • MestpKO and biallelic Mest inactivation (MestgKO) female mice displayed normal maternal behaviors and instincts, with complete abrogation of Mest mRNA without affecting miR-335.

Conclusions:

  • Loss of Mest does not result in discernible impairments in object recognition memory, social behavior, or maternal behavior.
  • The discrepancy in maternal behavioral phenotypes between different Mest knockout models warrants further investigation.