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Updated: Sep 4, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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AA amyloidosis associated with cancers.

Joyita Bharati^1,2, Oscar B Lahoud³, Kenar D Jhaveri²

¹Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|July 22, 2022

Summary

Systemic AA amyloidosis is linked to cancer, particularly renal cell carcinoma and hematological malignancies. Treatment focuses on the underlying cancer or immune therapy withdrawal.

Keywords:

AA amyloidosis onconephrology paraneoplastic syndrome renal cell carcinoma solid cancer

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Area of Science:

Oncology
Nephrology
Immunology

Background:

Systemic AA amyloidosis is a rare condition linked to chronic inflammation, autoimmune disorders, and infections.
It frequently impacts kidney function and is associated with various malignancies, including renal cell carcinoma (RCC) and hematological disorders.
AA amyloidosis can also occur in patients treated with immune checkpoint inhibitors.

Approach:

This review synthesizes current understanding of the association between cancer and systemic AA amyloidosis.
It explores the clinical presentations, pathological types, and underlying mechanisms.
The review discusses the role of the tumor microenvironment and immune therapy in disease pathogenesis.

Key Points:

Renal cell carcinoma (RCC) accounts for a significant proportion of solid tumors associated with AA amyloidosis, often presenting with renal symptoms.
Hematological malignancies, such as monoclonal gammopathy and lymphoma, are also linked to AA amyloidosis.
Immune checkpoint inhibitors (e.g., pembrolizumab, nivolumab) have been associated with AA amyloidosis development.

Conclusions:

The association between cancer and AA amyloidosis is likely mediated by immune responses exacerbated by the tumor or its treatment.
Management primarily involves treating the underlying malignancy or discontinuing offending immune therapies.
Understanding this rare but severe condition is crucial for timely diagnosis and effective patient management.