Recent progress in analytical capillary isotachophoresis (2018 - March 2022)

Area of Science:

• Analytical Chemistry
• Separation Science

Background:

• Analytical capillary and microchip isotachophoresis (CE/MI) have seen significant research activity.
• The period from 2018 to early 2022 has been a focus for advancements in these techniques.

Purpose of the Study:

• To review and summarize recent developments in analytical capillary and microchip isotachophoresis.
• To highlight theoretical, instrumental, and application-focused progress in the field.

Main Methods:

• Literature review of scientific papers published between 2018 and Q1 2022.
• Analysis of theoretical studies, instrumental innovations, and analytical applications.

Main Results:

• Theoretical research continues to advance fundamental knowledge, particularly through computer simulations for electrolyte system design.
• Instrumental developments include novel microfluidic devices and hyphenation with various detection techniques, yielding significant results.
• Analytical applications demonstrate the versatility and potential of contemporary isotachophoresis.

Conclusions:

• Despite not being a mass-scale technique, isotachophoresis maintains strong interest due to its unique features.
• Its application as both a standalone method and within multidimensional separation strategies is expanding.