Related Experiment Video

Updated: Sep 3, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K

Low-dose statins improve prognosis of patients with ischaemic stroke undergoing intra-arterial thrombectomy: A

Chaohua Cui1, Shuju Dong2, Qian Liu2

  • 1Department of Rehabilitation, Liuzhou Municipal Liutie Central Hospital, Liunan Distract, Liuzhou, Guangxi, China.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 22, 2022
PubMed

Insights

Low-dose statins improve outcomes for Asian patients undergoing thrombectomy for acute ischemic stroke. This treatment is linked to better neurological function, functional recovery, and reduced mortality, with no increase in bleeding risk.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • High-dose statins are recommended for stroke patients undergoing thrombectomy.
  • Low-dose statins are effective in Asian populations but their role in thrombectomy patients is unclear.
  • The study investigates the impact of low-dose statins on prognosis and bleeding risk in this patient group.

Purpose of the Study:

  • To evaluate the efficacy and safety of low-dose statin use in Asian patients with acute ischemic stroke undergoing intra-arterial thrombectomy.
  • To determine the association between low-dose statins and neurological improvement, functional outcomes, and mortality.
  • To assess the effect of low-dose statins on in-hospital hemorrhage events.

Main Methods:

  • Prospective data collection from patients undergoing intra-arterial thrombectomy for acute ischemic stroke.
  • Efficacy outcomes included National Institutes of Health Stroke Scale (NIHSS) score improvement at 7 days and favorable functional outcome (FFO) at 90 days.
  • Safety outcomes assessed in-hospital hemorrhage rates and 2-year mortality.

Main Results:

  • 256 patients were included in the study.
  • The low-dose statin group showed higher NIHSS improvement, higher FFO rates, and lower mortality compared to the control group.
  • Low-dose statin use was significantly associated with improved NIHSS scores (OR=1.773), FFO (OR=2.962), and reduced mortality (OR=0.554). A lower percentage of gastrointestinal hemorrhage was observed in the statin group.

Conclusions:

  • Low-dose statin use is significantly associated with improved neurological function at 7 days post-thrombectomy in Asian patients.
  • Low-dose statins are linked to better functional outcomes at 90 days and reduced mortality within 2 years.
  • The findings suggest low-dose statins are beneficial for Asian acute ischemic stroke patients undergoing thrombectomy, without increasing bleeding risk.
Abstract

Keywords:
Efficacy and safetyIntra-arterial thrombectomyLow-dose statinStroke

More Related Videos

Prehospital Thrombolysis: A Manual from Berlin05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.0K
Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area09:08

Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area

Published on: February 2, 2017

16.5K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
31
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
849
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
19
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
27
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
24
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
871