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Updated: Sep 3, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Low-Dose Rituximab for Bullous Pemphigoid. Protocol and Single-Center Experience.

C Suárez-Carantoña¹, J Jiménez-Cauhé², A González-García³

¹Internal Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain; Universidad de Alcalá, Alcalá de Henares, Spain.

Actas Dermo-Sifiliograficas

|July 22, 2022

Summary

This summary is machine-generated.

Low-dose rituximab effectively treats bullous pemphigoid (BP), offering steroid-sparing benefits and a favorable safety profile. This approach shows promise as a new therapeutic option for BP patients.

Keywords:

Bullous pemphigoid Interdisciplinar Interdisciplinary Penfigoide ampolloso Rituximab

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Area of Science:

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Dermatology
Pharmacology

Background:

Low-dose rituximab is an established treatment for various autoimmune diseases.
Previous studies indicate its efficacy and safety in pemphigus vulgaris.
The potential of low-dose rituximab for bullous pemphigoid (BP) remains to be fully explored.

Observation:

A pilot study treated six elderly patients (mean age 78.6 years) with BP using a single cycle of low-dose rituximab.
Treatment involved two 500mg infusions of rituximab, spaced two weeks apart.
Patients were monitored for early and late therapeutic endpoints.

Findings:

Rapid disease control was observed, with a mean time of 1.9 weeks to control and 4 weeks to the end of consolidation.
Four patients achieved significant remission, with three experiencing partial remission (minimal or no therapy) and one achieving complete remission (no therapy).
One patient relapsed and required further treatment, while another experienced a manageable adverse event (herpetic gingivostomatitis).

Implications:

Low-dose rituximab demonstrates acceptable remission rates and significant steroid-sparing effects in bullous pemphigoid.
This treatment offers a potentially safer and more cost-effective alternative compared to standard rituximab doses.
The findings suggest low-dose rituximab as a viable therapeutic option for managing bullous pemphigoid.