High-surface β-Ketoenamine linked covalent organic framework driving broad-spectrum solid phase microextraction on...

Area of Science:

• Analytical Chemistry
• Materials Science
• Environmental Science

Background:

• Aromatic esters are common in daily products but pose risks, necessitating sensitive analytical methods for regulation.
• Extracting diverse aromatic esters from complex cosmetic matrices is challenging due to their varied properties.
• Existing methods struggle with broad-spectrum and simultaneous extraction of these compounds.

Purpose of the Study:

• To develop a novel solid phase microextraction (SPME) coating for efficient extraction of aromatic esters.
• To establish a sensitive analytical method for determining multi-polar aromatic esters in cosmetic samples.
• To address the challenge of simultaneous extraction of diverse aromatic esters from complex matrices.

Main Methods:

• Synthesis of a covalent organic framework, DaTp (1, 3, 5-triformylphloroglucinol-2, 6-diaminoanthracene), as an SPME coating.
• Fabrication of a self-made SPME fiber using the synthesized DaTp material.
• Coupling the SPME fiber with gas chromatography-tandem mass spectrometry (GC-MS) for analysis.
• Utilizing hydrophobic interaction, π-π conjugation, and hydrogen bonding for analyte extraction.

Main Results:

• The DaTp-based SPME coating demonstrated high specific surface, excellent stability, and effective extraction of trace analytes with diverse polarity.
• The developed GC-MS method exhibited wide linear ranges, low limits of detection, and good repeatability and reproducibility.
• Precise quantification of aromatic esters in four cosmetic samples was achieved with satisfactory recoveries (80.7%-118%).

Conclusions:

• The novel DaTp covalent organic framework serves as a competitive SPME coating for broad-spectrum extraction of aromatic esters.
• The developed analytical method provides a sensitive and reliable approach for determining aromatic esters in complex cosmetic products.
• This advancement facilitates effective regulation and safety assessment of cosmetics containing aromatic esters.