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Related Experiment Video

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Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
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Recent developments in chitosan hydrogels carrying natural bioactive compounds.

Nga H N Do1, Quyen T Truong1, Phung K Le1

  • 1Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, Ho Chi Minh City, Viet Nam; Vietnam National University Ho Chi Minh City (VNU-HCM), Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Viet Nam.

Carbohydrate Polymers
|July 22, 2022
PubMed
Summary

Chitosan hydrogels effectively deliver natural compounds for disease treatment, overcoming phytochemical degradation. This review explores their properties, loading methods, and biomedical applications, highlighting challenges in controlled release.

Keywords:
BioactivityChitosan hydrogelControlled drug deliveryFabricationNatural extracts

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Natural Product Chemistry

Background:

  • Chitosan hydrogels offer biocompatibility and biodegradability for drug delivery.
  • Natural compounds show promise in disease treatment but face pharmacokinetic challenges.
  • Phytochemicals require effective delivery systems to overcome degradation and bioavailability issues.

Purpose of the Study:

  • To review chitosan hydrogel properties for drug delivery.
  • To explore methods for loading natural extracts onto hydrogels.
  • To discuss the biomedical applications and challenges of chitosan-hydrogel-natural compound systems.

Main Methods:

  • Literature review of chitosan hydrogel properties.
  • Analysis of natural extract loading techniques.
  • Evaluation of in vitro and in vivo studies on chitosan hydrogels carrying natural compounds.

Main Results:

  • Chitosan hydrogels exhibit tunable properties for flexible drug encapsulation and release.
  • Loading natural extracts onto hydrogels enhances phytochemical stability and delivery.
  • Various biomedical applications are demonstrated, with ongoing research into controlled release.

Conclusions:

  • Chitosan hydrogels are promising carriers for natural compounds in biomedical applications.
  • Further research is needed to optimize loading efficiency and control release kinetics.
  • Addressing physicochemical and pharmacokinetic challenges is crucial for clinical translation.