Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

31.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.7K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

187
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
187
Thermoregulation01:26

Thermoregulation

1.2K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoptic Neural Circuitry for Dramatic and Gentle Thermoregulation.

Neuroscience bulletin·2025
Same author

Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Confrontation experience against escaping bait improves pursuit strategy in mice.

The Journal of experimental biology·2024
Same author

Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem.

eLife·2024
Same author

Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing.

Science advances·2022
Same author

Single-neuron representation of learned complex sounds in the auditory cortex.

Nature communications·2020
Same journal

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026
Same journal

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026
Same journal

Transient distortions of the South Atlantic Anomaly radiation environments driven by electric fields.

Nature communications·2026
Same journal

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Nature communications·2026
Same journal

Structural and mechanistic insights into primer synthesis initiation by DNA primase.

Nature communications·2026
Same journal

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila
09:09

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila

Published on: January 13, 2014

8.2K

A temperature-regulated circuit for feeding behavior.

Shaowen Qian1,2, Sumei Yan3, Ruiqi Pang3,4

  • 1Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, School of Basic Medicine, Army Medical University, Chongqing, China. qianshaowen1110@163.com.

Nature Communications
|July 22, 2022
PubMed
Summary
This summary is machine-generated.

Mice use a specific brain region, the anteroventral and periventricular medial preoptic area (apMPOA), to control feeding behavior based on temperature. Distinct neuronal pathways within apMPOA promote or suppress food intake in response to cold or heat.

More Related Videos

A Do-it-yourself System for Scheduled Feeding of Laboratory Rodents in Their Home Cage
04:49

A Do-it-yourself System for Scheduled Feeding of Laboratory Rodents in Their Home Cage

Published on: June 6, 2025

325
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.0K

Related Experiment Videos

Last Updated: Sep 3, 2025

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila
09:09

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila

Published on: January 13, 2014

8.2K
A Do-it-yourself System for Scheduled Feeding of Laboratory Rodents in Their Home Cage
04:49

A Do-it-yourself System for Scheduled Feeding of Laboratory Rodents in Their Home Cage

Published on: June 6, 2025

325
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.0K

Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Homeostasis

Background:

  • Animals regulate food intake to maintain body temperature (thermal homeostasis).
  • Mechanisms linking ambient temperature to feeding behavior are not well understood.
  • The medial preoptic area (MPOA) is known for thermoregulation but its role in feeding is less explored.

Purpose of the Study:

  • To identify brain regions and neuronal circuits controlling temperature-dependent feeding behavior.
  • To investigate the role of the anteroventral and periventricular medial preoptic area (apMPOA) in feeding regulation.
  • To elucidate the cellular and molecular underpinnings of these circuits.

Main Methods:

  • Utilized mouse models to study feeding behavior in response to varying ambient temperatures.
  • Employed chemogenetics and caspase ablation to manipulate specific neuronal pathways.
  • Performed projection-specific RNA sequencing and fluorescence in situ hybridization for molecular characterization.

Main Results:

  • Identified distinct glutamatergic neuronal populations within the apMPOA mediating feeding.
  • Discovered that apMPOA neurons projecting to the arcuate nucleus sense low temperatures and increase food intake.
  • Found that apMPOA neurons projecting to the paraventricular hypothalamic nucleus (PVH) sense high temperatures and decrease food intake, with this pathway being crucial for temperature-dependent feeding.

Conclusions:

  • The apMPOA acts as a critical center for orchestrating feeding behavior in response to thermal challenges.
  • Two distinct neuronal populations within the apMPOA, marked by galanin and apelin receptors, differentially regulate feeding based on temperature.
  • These findings reveal novel neural circuits and cell populations involved in integrating temperature and feeding behavior.