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T1 values and extracellular volume fraction in asymptomatic subjects: variations in left ventricular segments and

Moon Young Kim1,2, Soo Jin Cho3, Hae Jin Kim4

  • 1Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Scientific Reports
|July 22, 2022
PubMed

Insights

Cardiac magnetic resonance imaging reveals differences in myocardial T1 values and extracellular volume fraction (ECV) across left ventricular segments. Cardiovascular risk factors like hypertension and diabetes significantly impact ECV, even in asymptomatic individuals.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Biomedical Engineering

Background:

  • Myocardial T1 values and extracellular volume fraction (ECV) are key metrics in cardiovascular magnetic resonance imaging (CMR).
  • Understanding variations in these metrics across left ventricular (LV) segments and their correlation with cardiovascular risk factors is crucial for early disease detection.

Purpose of the Study:

  • To evaluate variations in pre-contrast (preT1) and post-contrast (postT1) myocardial T1 values and ECV across LV segments.
  • To investigate correlations between these CMR-derived metrics and cardiovascular risk factors such as hypertension (HTN) and diabetes mellitus (DM).

Main Methods:

  • Cardiac MRI with preT1 and postT1 mapping was performed on 233 asymptomatic subjects using a 1.5-T scanner.
  • T1 values and ECV were analyzed across LV segments and correlated with age, sex, estimated glomerular filtration rate (eGFR), HTN, and DM status.

Main Results:

  • Significant differences in T1 values and ECV were observed between septal and lateral LV segments at mid-ventricular and basal levels.
  • The HTN-DM group exhibited significantly higher ECV compared to control and HTN-only groups.
  • Overall postT1 and ECV showed significant correlations with eGFR.

Conclusions:

  • Myocardial T1 values and ECV exhibit segmental variations within the LV.
  • Extracellular volume fraction is significantly influenced by hypertension, diabetes mellitus, and eGFR, even in asymptomatic individuals, highlighting their subclinical impact.

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