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Updated: Sep 3, 2025

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

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Phenotyping the hypertensive heart

Marijana Tadic1, Cesare Cuspidi2, Thomas H Marwick3,4

  • 1Klinik für Innere Medizin II, Universitätsklinikum Ulm, Albert-Einstein Allee 23, 89081 Ulm, Germany.

European Heart Journal
|July 23, 2022
PubMed

Insights

Advanced echocardiography techniques detect subclinical left ventricular impairment in patients with arterial hypertension. Early detection of cardiac remodelling can guide treatment to prevent cardiovascular events.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Hypertension Research

Background:

  • Arterial hypertension is a primary cardiovascular risk factor, contributing significantly to global disease burden.
  • Echocardiography is the standard for assessing cardiac damage in hypertensive individuals.
  • Subclinical left ventricular (LV) impairment is a key concern in hypertensive heart disease (HHD).

Purpose of the Study:

  • To review advanced imaging techniques for evaluating cardiac injury in arterial hypertension.
  • To highlight the role of novel echocardiographic methods in detecting subclinical LV impairment.
  • To discuss the differential diagnosis of LV hypertrophy in hypertensive patients.

Main Methods:

  • Review of current literature on advanced echocardiography (2D/3D speckle tracking, myocardial work).
  • Discussion of multimodality imaging (cardiac MRI, CT) for tissue characterization.
  • Analysis of imaging findings in the context of cardiovascular event genesis.

Main Results:

  • Novel echocardiographic techniques offer insights into subclinical LV impairment missed by conventional methods.
  • Cardiac remodelling detected by imaging represents intermediate stages toward cardiovascular events.
  • Multimodality imaging aids in distinguishing hypertensive heart disease from other causes of LV hypertrophy.

Conclusions:

  • Advanced imaging, including novel echocardiography and tissue characterization, improves HHD detection.
  • Identifying and treating cardiac remodelling can prevent or delay progressive disease and cardiovascular events.
  • Selective use of multimodality imaging is crucial for guiding treatment and avoiding disease progression.

Keywords:
Arterial hypertensionCardiac fibrosisCardiac magnetic resonanceComputed tomographyEchocardiographySpeckle-tracking echocardiography

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