Meta-analytical analysis on components released from resin-based dental materials.

Area of Science:

• Dental Materials Science
• Polymer Chemistry
• Biomaterials

Background:

• Dental resin-based materials are widely used in restorative dentistry.
• Concerns exist regarding the safety of substances released from these materials into the oral environment.

Purpose of the Study:

• To comprehensively review the literature from the last decade on elutable substances released from dental resin-based materials.
• To analyze the concentrations of these substances in various solvents.

Main Methods:

• A systematic literature search was conducted on PubMed, Scopus, and Web of Science from January 2010 to April 2022.
• 23 eligible studies were selected from 877 initial papers based on strict inclusion criteria.
• Analyzed eluted substance concentrations relative to sample surface area and volume, using 24-hour data as a reference.

Main Results:

• Hydroxyethyl methacrylate (HEMA), triethylene glycol dimethacrylate (TEGDMA), and bisphenol A (BPA) were the most frequently eluted substances.
• Bis-glycidyl methacrylate (Bis-GMA) and urethane dimethacrylate (UDMA) showed lower elution rates.
• Organic solvents significantly increased substance release compared to water-based solvents.
• A negative correlation was found between eluate molecular mass and release, and a positive correlation with specimen surface area.

Conclusions:

• The type of solvent, molecular mass of eluates, and specimen surface area and volume significantly influence the release of substances from dental resins.
• Clinical procedures may benefit from using dental materials with monomers exhibiting reduced elution tendencies.