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Updated: Sep 3, 2025
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Evaluation of Left Ventricular Function by Three-Dimensional Speckle-Tracking Echocardiography in Patients with
Yu-Bo Wang1,2, Hui Huang1, Shan Lin1
1Department of Ultrasound, Third People's Hospital of Hubei Province, Jianghan University, Wuhan, 430033, China.
Insights
Three-dimensional speckle-tracking echocardiography reveals impaired left ventricular systolic function and increased myocardial mass in chronic kidney failure (CKF) patients. These findings indicate myocardial remodeling and dysfunction in CKF.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Chronic kidney failure (CKF) is associated with cardiovascular complications.
- Left ventricular systolic function is a key indicator of cardiac health.
- Advanced echocardiography techniques can provide detailed functional assessments.
Purpose of the Study:
- To quantitatively assess left ventricular systolic function in CKF patients using 3D speckle-tracking echocardiography.
- To identify specific patterns of myocardial dysfunction and remodeling in CKF.
Main Methods:
- 30 CKF patients underwent 2D and 3D transthoracic echocardiography.
- Calculated left ventricular ejection fraction, mass, and global strains (longitudinal, circumferential, area, radial).
- Compared parameters between CKF patients and a control group.
Main Results:
- CKF patients showed significantly lower ejection fraction, GLS, GCS, GAS, and GRS compared to controls.
- These strain parameters correlated well with ejection fraction.
- CKF patients with normal ejection fraction still exhibited reduced strain and increased LV mass.
- Hypertensive CKF patients had lower systolic function parameters and higher myocardial mass.
Conclusions:
- 3D speckle-tracking echocardiography parameters (GLS, GCS, GAS, GRS) are reduced in CKF patients.
- Increased left ventricular mass in CKF suggests myocardial remodeling.
- These findings demonstrate impaired myocardial contraction function and remodeling in CKF.
Objective:
To establish a quantitative evaluation of the left ventricle's systolic function in patients with chronic kidney failure (CKF) by three-dimensional speckle-tracking echocardiography.
Methods:
Two-dimensional and three-dimensional transthoracic echocardiography was performed on 30 patients with CKF. The ejection fraction, mass and global peak longitudinal strain, global circumferential strain, global area strain, and global radial strain of the left ventricle were calculated.
Results:
The ejection fraction, mass and global peak longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS) in the CKF group were significantly lower than those in the control group. Simultaneously, the GLS, GCS, GAS and GRS were well correlated with the ejection fraction. For patients with normal ejection fraction in the CKF group, the GLS, GCS, GAS and GRS were lower than those in the control group, while the left ventricular mass was significantly higher in CKF patients than in the control group. For patients with hypertension in the CKF group, ejection fraction, GLS, GCS, GAS and GRS calculated using three-dimensional echocardiography were significantly lower than those in patients with normal blood pressure; however, the myocardial mass was higher.
Conclusions:
The parameters (GLS, GCS, GAS and GRS) calculated using three-dimensional speckle-tracking software were lower in the CKF group. Simultaneously, the left ventricular mass was higher in CFK patients than in the control group, thus showing that the myocardial contraction function was impaired and that myocardial remodeling had occurred.
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