Response variation as a result of tai chi on resting blood pressure in hypertensive adults: An aggregate data meta-analysis

Determine if inter-individual response differences (IIRD) are present with respect to tai chi as a treatment for high blood pressure in adults with hypertension.

Using the aggregate data meta-analytic approach, seven randomized controlled trials (RCTs) representing 503 hypertensive participants from a recent meta-analysis of tai chi on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) were included. Tai chi and control group change outcome standard deviations treated as point estimates for both resting SBP and DBP were used to calculate true IIRD from each study. The inverse variance heterogeneity (IVhet) model was used to pool results.

Among adults with hypertension, statistically and clinically significant reductions in resting SBP (X‾, -8.68 mmHg, 95% CI, -9.55 to -7.81) and DBP (X‾, -4.42 mmHg, 95% CI, -5.71 to -3.13) were observed as an effect of practicing tai chi. In the same population, neither statistically nor clinically significant true IIRD was observed for resting SBP (X‾, -0.47 mmHg, 95% CI -5.13 to 5.08) while statistically, but not clinically significant differences were observed for resting DBP (X‾, 1.97 mmHg, 95% CI, 1.02 to 2.60).

The current findings suggest that while reductions in resting SBP and DBP were observed, a search for potential moderators and mediators for tai-chi-associated changes in resting DBP but not SBP may be warranted. However, a need exists for additional well-designed RCTs, including those from other countries, before a greater level of certainty can be established.