Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral vascular responses to fluorocarbon administration.

N S Faithfull, C E King, S M Cain

    Microvascular Research
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns.

    Behavioural brain research·2020
    Same author

    Postoperative continuous non-invasive cardiac output monitoring on the ward: a feasibility study.

    Journal of clinical monitoring and computing·2020
    Same author

    Increased exposure of plankton to arsenic in contaminated weakly-stratified lakes.

    The Science of the total environment·2018
    Same author

    Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking.

    Neuropharmacology·2015
    Same author

    Thermomicrobium carboxidum sp. nov., and Thermorudis peleae gen. nov., sp. nov., carbon monoxide-oxidizing bacteria isolated from geothermally heated biofilms.

    International journal of systematic and evolutionary microbiology·2014
    Same author

    A ventilatory effect of carbonic anhydrase inhibition in man.

    Project report. USAF School of Aviation Medicine·2014

    Oxygenated fluorocarbons increased skeletal muscle vascular heterogeneity during hypoxia. This effect, linked to a hypotensive reaction, may impair oxygen delivery and extraction during altered oxygen states.

    Area of Science:

    • Physiology
    • Cardiovascular Science
    • Microcirculation

    Background:

    • Skeletal muscle vasculature plays a crucial role in oxygen delivery.
    • Understanding the local effects of interventions like fluorocarbon emulsions on microcirculation is vital.

    Purpose of the Study:

    • To investigate the local effects of oxygenated versus deoxygenated fluorocarbon emulsions on skeletal muscle vasculature.
    • To assess the impact of hyperoxia and hypoxia on perfusion heterogeneity.

    Main Methods:

    • Utilized anesthetized dogs, infusing oxygenated (F-O2) or deoxygenated (F-N2) fluorocarbon emulsions into the hindlimb.
    • Measured red blood cell washout curves to determine perfusion heterogeneity using a gamma index.
    • Recorded responses during normoxia and hypoxic hypoxia.

    Related Experiment Videos

    Main Results:

    • Fluorocarbon emulsion infusion initially increased perfusion heterogeneity (gamma index).
    • Oxygenated fluorocarbons (F-O2) maintained greater heterogeneity during hypoxia compared to F-N2.
    • Increased heterogeneity correlated with hypotensive reactions and inversely with oxygen extraction capacity.

    Conclusions:

    • Transient fluorocarbon reactions, potentially via complement activation, can blunt microcirculatory reactivity to hyperoxia and hypoxia.
    • This blunting may impair the skeletal muscle's ability to adjust oxygen delivery and extraction under varying oxygen conditions.