Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generalized conservation equation for multicompartmental systems.

R S Adler

    Medical Physics
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dialysis-related Arthropathy in Patients on Long-term Hemodialysis: Radiographic Features.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Power Doppler sonography in the diagnosis of hemophilic synovitis--a promising tool.

    Journal of thrombosis and haemostasis : JTH·2008
    Same author

    Use of ultrasonographic guidance for needle localization of osteoid osteoma of the capitate.

    HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2008
    Same author

    Ultrasound in the detection and treatment of a painful stump neuroma.

    Skeletal radiology·2003
    Same author

    On the relationship between power mode and pressure amplitude decorrelation.

    Ultrasound in medicine & biology·2001
    Same author

    Use of ultrasonographic guidance in interventional musculoskeletal procedures: a review from a single institution.

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2001
    Same journal

    Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

    Medical physics·2026
    Same journal

    Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

    Medical physics·2026
    Same journal

    Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

    Medical physics·2026
    Same journal

    Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

    Medical physics·2026
    Same journal

    Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

    Medical physics·2026
    Same journal

    Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

    Medical physics·2026
    See all related articles

    This study introduces a new equation for tissue tracer content using projection operators. It accounts for complex tracer kinetics and offers insights into tissue heterogeneity and trapping.

    Area of Science:

    • Pharmacokinetics and Tracer Kinetics
    • Biomedical Engineering
    • Mathematical Modeling in Biology

    Background:

    • Understanding tracer dynamics in tissues is crucial for diagnostic imaging and therapeutic monitoring.
    • Current models often simplify complex multicompartmental kinetics, potentially limiting accuracy.
    • Accurate quantification of tracer behavior is essential for various biomedical applications.

    Purpose of the Study:

    • To derive a novel equation for local tissue tracer content (Q(t)) using a projection operator technique.
    • To incorporate linear multicompartmental kinetics into tracer utilization models.
    • To evaluate the relationship between the new model and existing methods like effective single compartmental analysis.

    Main Methods:

    • Utilized a projection operator technique to derive the governing equation.

    Related Experiment Videos

  • Assumed linear multicompartmental kinetics for tracer utilization.
  • Introduced new parameters (lambda, xi(t), psi(t)) to represent tissue complexity, with time-dependent coefficients as sums of exponentials.

    • Main Results:

    • Derived an equation for local tissue tracer content (Q(t)) dependent on local blood flow (F) and tracer concentration (Ca(t)).
    • Demonstrated the model's ability to account for tissue heterogeneity and internal tracer trapping.
    • Evaluated the connection between the derived model and effective single compartmental analysis.

    Conclusions:

    • The developed projection operator technique provides a more comprehensive model for local tissue tracer content.
    • The new parameters effectively capture tissue complexity, improving tracer kinetic analysis.
    • This approach offers a potential advancement for methods like local cerebral blood flow determination.