Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ferrokinetic studies with stable isotopes as tracers.

M C Cantone, N Molho, L Pirola

    Medical Physics
    |March 1, 1987
    PubMed
    Summary

    This study developed a new method for ferrokinetic studies using stable iron isotopes. The technique accurately measured iron absorption and plasma clearance in rabbits, showing good agreement with radioactive tracers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The benefits and societal importance of pig welfare in slaughterhouses a narrative review.

    Meat science·2025
    Same author

    The Magnetic Search Coil (MSC) on the TRACERS Mission.

    Space science reviews·2025
    Same author

    Low latency optical-based mode tracking with machine learning deployed on FPGAs on a tokamak.

    The Review of scientific instruments·2024
    Same author

    Tangential extreme ultraviolet and soft x-ray diagnostic system for time-resolved temperature measurement on the High Beta Tokamak-Extended Pulse.

    The Review of scientific instruments·2023
    Same author

    Assistance dogs help reduce mental health symptoms among Australian Defence Force veterans and emergency services personnel: A pilot study.

    Psychiatry research·2023
    Same author

    Feasibility study of a high spatial and time resolution beam emission spectroscopy diagnostic for localized density fluctuation measurements in Lithium Tokamak eXperiment-β (LTX-β).

    The Review of scientific instruments·2022

    Area of Science:

    • Biomedical Science
    • Nuclear Medicine
    • Animal Research

    Background:

    • Ferrokinetic studies are crucial for understanding iron metabolism.
    • Traditional methods often rely on radioactive iron isotopes, which pose handling and disposal challenges.
    • Stable iron isotopes offer a safer alternative for in vivo studies.

    Purpose of the Study:

    • To develop and validate a novel methodology for ferrokinetic studies using stable iron isotopes.
    • To determine fractional plasma clearance and intestinal iron absorption in rabbits.
    • To compare the accuracy of stable iron isotope measurements with traditional radioactive methods.

    Main Methods:

    • Administration of iron stable isotopes (58Fe intravenously, 57Fe orally) to rabbits.
    • Utilized a double tracer technique for simultaneous measurement.

    Related Experiment Videos

  • Analyzed iron isotope content in plasma samples using proton nuclear activation.
  • Compared results with those obtained using radioactive iron isotopes (55Fe and 59Fe).

    • Main Results:

    • Successfully developed a methodology for ferrokinetic studies using stable iron isotopes.
    • Fractional plasma clearance and intestinal iron absorption were accurately determined in rabbits.
    • Results obtained with stable isotopes showed satisfactory agreement with radioactive isotopes.

    Conclusions:

    • Stable iron isotopes provide a reliable and safe alternative for ferrokinetic studies.
    • The developed methodology is effective for assessing iron metabolism in animal models.
    • This approach has potential applications in clinical settings for iron status assessment.