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Soluble (Pro)Renin Receptor in Hypertension
1Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Nephron
|July 24, 2022
Summary
The (pro)renin receptor (PRR) plays a key role in blood pressure regulation. Its soluble form, sPPR, is increasingly recognized for mediating hypertensive actions, particularly in the kidney.
Area of Science:
- Nephrology
- Cardiovascular Physiology
Background:
- The (pro)renin receptor (PRR) is a single-transmembrane protein involved in numerous physiological and pathological processes.
- PRR activation in the kidney leads to sodium and water retention, elevating blood pressure.
- The intrarenal renin-angiotensin system is partially activated by renal PRR actions.
Purpose of the Study:
- To review recent findings on the role of soluble (pro)renin receptor (sPPR) in hypertension.
- To explore the mechanisms by which PRR influences blood pressure.
- To summarize the generation and functions of PRR isoforms.
Main Methods:
- Literature review of studies on PRR and hypertension.
- Analysis of research on protease-mediated cleavage of PRR.
- Examination of data from animal models of hypertension.
Main Results:
- The prohypertensive effects of renal PRR are largely mediated by the 28-kDa soluble form (sPPR).
- Protease-mediated cleavage of PRR generates multiple isoforms, contributing to its diverse functions.
- sPPR plays a significant role in the development of hypertension in various animal models.
Conclusions:
- Soluble (pro)renin receptor (sPPR) is a key mediator of renal PRR's hypertensive actions.
- Understanding PRR isoforms and sPPR is crucial for comprehending blood pressure regulation.
- Further research into sPPR in animal models will elucidate its role in hypertension.
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