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Cerebellar Regional Dissection for Molecular Analysis
08:51

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[Epstein-Barr virus-associated subacute sensorimotor neuropathy with multiple cerebellar microbleeding: a case

Mayumi Furuya1, Satoru Oji1, Kohei Sugimoto1

  • 1Department of Neurology, Saitama Medical Center, Saitama Medical University.

Rinsho Shinkeigaku = Clinical Neurology
|July 24, 2022
PubMed

Insights

Epstein-Barr virus (EBV) reactivation can cause subacute sensorimotor neuropathy, presenting as limb weakness and visual disturbances. This case highlights EBV-associated vasculitis and demyelinating neuropathy, successfully treated with corticosteroids.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Subacute sensorimotor neuropathy can be associated with various infections.
  • Epstein-Barr virus (EBV) is a common herpesvirus with diverse clinical manifestations.
  • Neurological complications of EBV reactivation are rare but can be severe.

Observation:

  • An 82-year-old male presented with diplopia and gait disturbance due to limb weakness.
  • Cervical lymph node biopsy revealed numerous EBV-positive cells, and EBV-DNA was detected in blood.
  • Nerve conduction studies indicated mixed axonal damage and demyelination.

Findings:

  • Brain MRI showed cerebellar microbleeds, suggesting EBV-related vasculitis.
  • Cerebrospinal fluid EBV-PCR was negative.
  • The patient's neuropathy likely resulted from a combination of vasculitic and immune-mediated demyelinating processes.

Implications:

  • This case highlights EBV reactivation as a potential cause of complex neurological syndromes.
  • Early diagnosis and corticosteroid therapy can lead to significant recovery in EBV-associated neuropathies.
  • Understanding the pathogenesis of EBV-related neurological disorders is crucial for effective management.
Keywords:
Epstein–Barr viruscerebral hemorrhageneuropathyreactivation

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